Stereospecific prevention by 17β‐estradiol of MPTP‐induced dopamine depletion in mice
Identifieur interne : 000297 ( France/Analysis ); précédent : 000296; suivant : 000298Stereospecific prevention by 17β‐estradiol of MPTP‐induced dopamine depletion in mice
Auteurs : Sophie Callier [Canada, France] ; Marc Morissette [Canada] ; Michelle Grbois [Canada] ; Thérèse Di Paolo [Canada]Source :
- Synapse [ 0887-4476 ] ; 2000-09-15.
English descriptors
- KwdEn :
- 17α‐estradiol, 17β‐estradiol, 3,4-Dihydroxyphenylacetic Acid (metabolism), Animals, Carrier Proteins (analysis), Carrier Proteins (genetics), Carrier Proteins (metabolism), Corpus Striatum (chemistry), Corpus Striatum (drug effects), Corpus Striatum (metabolism), Dopamine (deficiency), Dopamine (metabolism), Dopamine Plasma Membrane Transport Proteins, Estradiol (pharmacology), Gene Expression (drug effects), Homovanillic Acid (metabolism), MPTP, MPTP Poisoning (drug therapy), MPTP Poisoning (metabolism), MPTP Poisoning (prevention & control), Male, Membrane Glycoproteins, Membrane Transport Proteins, Mice, Mice, Inbred C57BL, Nerve Tissue Proteins, Piperazines (metabolism), Piperazines (pharmacology), RNA, Messenger (analysis), Radioligand Assay, Receptors, Estrogen (metabolism), Substantia Nigra (chemistry), Substantia Nigra (drug effects), Substantia Nigra (metabolism), Tritium, dopamine, dopamine transporter, striatum.
- MESH :
- chemical , analysis : Carrier Proteins, RNA, Messenger.
- chemical , deficiency : Dopamine.
- chemical , genetics : Carrier Proteins.
- chemical , metabolism : 3,4-Dihydroxyphenylacetic Acid, Carrier Proteins, Dopamine, Homovanillic Acid, Piperazines, Receptors, Estrogen.
- chemistry : Corpus Striatum, Substantia Nigra.
- drug effects : Corpus Striatum, Gene Expression, Substantia Nigra.
- drug therapy : MPTP Poisoning.
- metabolism : Corpus Striatum, MPTP Poisoning, Substantia Nigra.
- chemical , pharmacology : Estradiol, Piperazines.
- prevention & control : MPTP Poisoning.
- Animals, Dopamine Plasma Membrane Transport Proteins, Male, Membrane Glycoproteins, Membrane Transport Proteins, Mice, Mice, Inbred C57BL, Nerve Tissue Proteins, Radioligand Assay, Tritium.
Abstract
Neuroprotective activity of estrogens is reported in Alzheimer disease and recently has also been suggested for Parkinson disease, a disease affecting more men than women. To characterize this estrogenic activity, we studied the effects of 17β‐ and 17α‐estradiol treatment (1 μg twice daily 5 days before, during the day of four MPTP (15 mg/kg) injections, and for the following 5 days) on dopamine striatal toxicity induced by the neurotoxin MPTP in retired breeder male C57BL/6 mice. Striatal dopamine concentrations and its metabolites dihydroxyphenylacetic acid and homovanillic acid measured by HPLC in MPTP mice that received 17β‐estradiol were comparable to control animals, whereas MPTP mice treated with saline or 17α‐estradiol showed important decreases of dopamine and its metabolites. Striatal serotonin and its metabolite 5‐hydroxyindoleacetic acid concentrations remained unchanged after MPTP and treatments with steroids. Striatal [3H]GBR 12935 binding autoradiography to the dopamine transporter was as extensively decreased and correlated with dopamine depletion in MPTP mice, whereas this transporter mRNA decrease in the substantia nigra pars compacta was less pronounced. Treatment with steroids did not significantly change [3H]GBR 12935 binding, whereas dopamine transporter mRNA levels were not significantly different from controls. Under the present paradigm in retired breeder male mice, our results show dopaminergic and stereospecificity of estradiol to augment dopamine levels in MPTP‐lesioned mice without protecting against the extensive loss of dopamine terminals and moderate cell body loss. Synapse 37:245–251, 2000. © 2000 Wiley‐Liss, Inc.
Url:
DOI: 10.1002/1098-2396(20000915)37:4<245::AID-SYN1>3.0.CO;2-5
Affiliations:
Links toward previous steps (curation, corpus...)
- to stream Istex, to step Corpus: 000608
- to stream Istex, to step Curation: 000608
- to stream Istex, to step Checkpoint: 001161
- to stream PubMed, to step Corpus: 001618
- to stream PubMed, to step Curation: 001618
- to stream PubMed, to step Checkpoint: 001618
- to stream Ncbi, to step Merge: 000106
- to stream Ncbi, to step Curation: 000106
- to stream Ncbi, to step Checkpoint: 000106
- to stream Main, to step Merge: 003968
- to stream Main, to step Curation: 003440
- to stream Main, to step Exploration: 003440
- to stream France, to step Extraction: 000297
Links to Exploration step
ISTEX:4D2CD72C7E2B927E2AF68157BB11DCFC5A9F3D2CLe document en format XML
<record><TEI wicri:istexFullTextTei="biblStruct"><teiHeader><fileDesc><titleStmt><title xml:lang="en">Stereospecific prevention by 17β‐estradiol of MPTP‐induced dopamine depletion in mice</title><author><name sortKey="Callier, Sophie" sort="Callier, Sophie" uniqKey="Callier S" first="Sophie" last="Callier">Sophie Callier</name></author><author><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name></author><author><name sortKey="Grbois, Michelle" sort="Grbois, Michelle" uniqKey="Grbois M" first="Michelle" last="Grbois">Michelle Grbois</name></author><author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name></author></titleStmt><publicationStmt><idno type="wicri:source">ISTEX</idno><idno type="RBID">ISTEX:4D2CD72C7E2B927E2AF68157BB11DCFC5A9F3D2C</idno><date when="2000" year="2000">2000</date><idno type="doi">10.1002/1098-2396(20000915)37:4<245::AID-SYN1>3.0.CO;2-5</idno><idno type="url">https://api-v5.istex.fr/document/4D2CD72C7E2B927E2AF68157BB11DCFC5A9F3D2C/fulltext/pdf</idno><idno type="wicri:Area/Istex/Corpus">000608</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Corpus" wicri:corpus="ISTEX">000608</idno><idno type="wicri:Area/Istex/Curation">000608</idno><idno type="wicri:Area/Istex/Checkpoint">001161</idno><idno type="wicri:explorRef" wicri:stream="Istex" wicri:step="Checkpoint">001161</idno><idno type="wicri:doubleKey">0887-4476:2000:Callier S:stereospecific:prevention:by</idno><idno type="wicri:source">PubMed</idno><idno type="RBID">pubmed:10891861</idno><idno type="wicri:Area/PubMed/Corpus">001618</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Corpus" wicri:corpus="PubMed">001618</idno><idno type="wicri:Area/PubMed/Curation">001618</idno><idno type="wicri:explorRef" wicri:stream="PubMed" wicri:step="Curation">001618</idno><idno type="wicri:Area/PubMed/Checkpoint">001618</idno><idno type="wicri:explorRef" wicri:stream="Checkpoint" wicri:step="PubMed">001618</idno><idno type="wicri:Area/Ncbi/Merge">000106</idno><idno type="wicri:Area/Ncbi/Curation">000106</idno><idno type="wicri:Area/Ncbi/Checkpoint">000106</idno><idno type="wicri:doubleKey">0887-4476:2000:Callier S:stereospecific:prevention:by</idno><idno type="wicri:Area/Main/Merge">003968</idno><idno type="wicri:Area/Main/Curation">003440</idno><idno type="wicri:Area/Main/Exploration">003440</idno><idno type="wicri:Area/France/Extraction">000297</idno></publicationStmt><sourceDesc><biblStruct><analytic><title level="a" type="main" xml:lang="en">Stereospecific prevention by 17β‐estradiol of MPTP‐induced dopamine depletion in mice</title><author><name sortKey="Callier, Sophie" sort="Callier, Sophie" uniqKey="Callier S" first="Sophie" last="Callier">Sophie Callier</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherches en Endocrinologie Moléculaire, Le Centre Hospitalier Universitaire de Québec, Pavillon CHUL, Québec, Qc, G1V 4G2, and Faculty of Pharmacy, Laval University, Québec, Qc, G1K 7P4</wicri:regionArea><wicri:noRegion>G1K 7P4</wicri:noRegion></affiliation><affiliation wicri:level="3"><country xml:lang="fr">France</country><wicri:regionArea>INSERM Unit 339, St.‐Antoine Hospital, 75012 Paris</wicri:regionArea><placeName><region type="region" nuts="2">Île-de-France</region><settlement type="city">Paris</settlement></placeName></affiliation></author><author><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherches en Endocrinologie Moléculaire, Le Centre Hospitalier Universitaire de Québec, Pavillon CHUL, Québec, Qc, G1V 4G2, and Faculty of Pharmacy, Laval University, Québec, Qc, G1K 7P4</wicri:regionArea><wicri:noRegion>G1K 7P4</wicri:noRegion></affiliation></author><author><name sortKey="Grbois, Michelle" sort="Grbois, Michelle" uniqKey="Grbois M" first="Michelle" last="Grbois">Michelle Grbois</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherches en Endocrinologie Moléculaire, Le Centre Hospitalier Universitaire de Québec, Pavillon CHUL, Québec, Qc, G1V 4G2, and Faculty of Pharmacy, Laval University, Québec, Qc, G1K 7P4</wicri:regionArea><wicri:noRegion>G1K 7P4</wicri:noRegion></affiliation></author><author><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><affiliation wicri:level="1"><country xml:lang="fr">Canada</country><wicri:regionArea>Centre de Recherches en Endocrinologie Moléculaire, Le Centre Hospitalier Universitaire de Québec, Pavillon CHUL, Québec, Qc, G1V 4G2, and Faculty of Pharmacy, Laval University, Québec, Qc, G1K 7P4</wicri:regionArea><wicri:noRegion>G1K 7P4</wicri:noRegion></affiliation><affiliation></affiliation></author></analytic><monogr></monogr><series><title level="j">Synapse</title><title level="j" type="abbrev">Synapse</title><idno type="ISSN">0887-4476</idno><idno type="eISSN">1098-2396</idno><imprint><publisher>John Wiley & Sons, Inc.</publisher><pubPlace>New York</pubPlace><date type="published" when="2000-09-15">2000-09-15</date><biblScope unit="volume">37</biblScope><biblScope unit="issue">4</biblScope><biblScope unit="page" from="245">245</biblScope><biblScope unit="page" to="251">251</biblScope></imprint><idno type="ISSN">0887-4476</idno></series><idno type="istex">4D2CD72C7E2B927E2AF68157BB11DCFC5A9F3D2C</idno><idno type="DOI">10.1002/1098-2396(20000915)37:4<245::AID-SYN1>3.0.CO;2-5</idno><idno type="ArticleID">SYN1</idno></biblStruct></sourceDesc><seriesStmt><idno type="ISSN">0887-4476</idno></seriesStmt></fileDesc><profileDesc><textClass><keywords scheme="KwdEn" xml:lang="en"><term>17α‐estradiol</term><term>17β‐estradiol</term><term>3,4-Dihydroxyphenylacetic Acid (metabolism)</term><term>Animals</term><term>Carrier Proteins (analysis)</term><term>Carrier Proteins (genetics)</term><term>Carrier Proteins (metabolism)</term><term>Corpus Striatum (chemistry)</term><term>Corpus Striatum (drug effects)</term><term>Corpus Striatum (metabolism)</term><term>Dopamine (deficiency)</term><term>Dopamine (metabolism)</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Estradiol (pharmacology)</term><term>Gene Expression (drug effects)</term><term>Homovanillic Acid (metabolism)</term><term>MPTP</term><term>MPTP Poisoning (drug therapy)</term><term>MPTP Poisoning (metabolism)</term><term>MPTP Poisoning (prevention & control)</term><term>Male</term><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Nerve Tissue Proteins</term><term>Piperazines (metabolism)</term><term>Piperazines (pharmacology)</term><term>RNA, Messenger (analysis)</term><term>Radioligand Assay</term><term>Receptors, Estrogen (metabolism)</term><term>Substantia Nigra (chemistry)</term><term>Substantia Nigra (drug effects)</term><term>Substantia Nigra (metabolism)</term><term>Tritium</term><term>dopamine</term><term>dopamine transporter</term><term>striatum</term></keywords><keywords scheme="MESH" type="chemical" qualifier="analysis" xml:lang="en"><term>Carrier Proteins</term><term>RNA, Messenger</term></keywords><keywords scheme="MESH" type="chemical" qualifier="deficiency" xml:lang="en"><term>Dopamine</term></keywords><keywords scheme="MESH" type="chemical" qualifier="genetics" xml:lang="en"><term>Carrier Proteins</term></keywords><keywords scheme="MESH" type="chemical" qualifier="metabolism" xml:lang="en"><term>3,4-Dihydroxyphenylacetic Acid</term><term>Carrier Proteins</term><term>Dopamine</term><term>Homovanillic Acid</term><term>Piperazines</term><term>Receptors, Estrogen</term></keywords><keywords scheme="MESH" qualifier="chemistry" xml:lang="en"><term>Corpus Striatum</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="drug effects" xml:lang="en"><term>Corpus Striatum</term><term>Gene Expression</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" qualifier="drug therapy" xml:lang="en"><term>MPTP Poisoning</term></keywords><keywords scheme="MESH" qualifier="metabolism" xml:lang="en"><term>Corpus Striatum</term><term>MPTP Poisoning</term><term>Substantia Nigra</term></keywords><keywords scheme="MESH" type="chemical" qualifier="pharmacology" xml:lang="en"><term>Estradiol</term><term>Piperazines</term></keywords><keywords scheme="MESH" qualifier="prevention & control" xml:lang="en"><term>MPTP Poisoning</term></keywords><keywords scheme="MESH" xml:lang="en"><term>Animals</term><term>Dopamine Plasma Membrane Transport Proteins</term><term>Male</term><term>Membrane Glycoproteins</term><term>Membrane Transport Proteins</term><term>Mice</term><term>Mice, Inbred C57BL</term><term>Nerve Tissue Proteins</term><term>Radioligand Assay</term><term>Tritium</term></keywords></textClass><langUsage><language ident="en">en</language></langUsage></profileDesc></teiHeader><front><div type="abstract" xml:lang="en">Neuroprotective activity of estrogens is reported in Alzheimer disease and recently has also been suggested for Parkinson disease, a disease affecting more men than women. To characterize this estrogenic activity, we studied the effects of 17β‐ and 17α‐estradiol treatment (1 μg twice daily 5 days before, during the day of four MPTP (15 mg/kg) injections, and for the following 5 days) on dopamine striatal toxicity induced by the neurotoxin MPTP in retired breeder male C57BL/6 mice. Striatal dopamine concentrations and its metabolites dihydroxyphenylacetic acid and homovanillic acid measured by HPLC in MPTP mice that received 17β‐estradiol were comparable to control animals, whereas MPTP mice treated with saline or 17α‐estradiol showed important decreases of dopamine and its metabolites. Striatal serotonin and its metabolite 5‐hydroxyindoleacetic acid concentrations remained unchanged after MPTP and treatments with steroids. Striatal [3H]GBR 12935 binding autoradiography to the dopamine transporter was as extensively decreased and correlated with dopamine depletion in MPTP mice, whereas this transporter mRNA decrease in the substantia nigra pars compacta was less pronounced. Treatment with steroids did not significantly change [3H]GBR 12935 binding, whereas dopamine transporter mRNA levels were not significantly different from controls. Under the present paradigm in retired breeder male mice, our results show dopaminergic and stereospecificity of estradiol to augment dopamine levels in MPTP‐lesioned mice without protecting against the extensive loss of dopamine terminals and moderate cell body loss. Synapse 37:245–251, 2000. © 2000 Wiley‐Liss, Inc.</div></front></TEI><affiliations><list><country><li>Canada</li><li>France</li></country><region><li>Île-de-France</li></region><settlement><li>Paris</li></settlement></list><tree><country name="Canada"><noRegion><name sortKey="Callier, Sophie" sort="Callier, Sophie" uniqKey="Callier S" first="Sophie" last="Callier">Sophie Callier</name></noRegion><name sortKey="Di Paolo, Therese" sort="Di Paolo, Therese" uniqKey="Di Paolo T" first="Thérèse" last="Di Paolo">Thérèse Di Paolo</name><name sortKey="Grbois, Michelle" sort="Grbois, Michelle" uniqKey="Grbois M" first="Michelle" last="Grbois">Michelle Grbois</name><name sortKey="Morissette, Marc" sort="Morissette, Marc" uniqKey="Morissette M" first="Marc" last="Morissette">Marc Morissette</name></country><country name="France"><region name="Île-de-France"><name sortKey="Callier, Sophie" sort="Callier, Sophie" uniqKey="Callier S" first="Sophie" last="Callier">Sophie Callier</name></region></country></tree></affiliations></record>Pour manipuler ce document sous Unix (Dilib)
EXPLOR_STEP=$WICRI_ROOT/Wicri/Canada/explor/ParkinsonCanadaV1/Data/France/Analysis
HfdSelect -h $EXPLOR_STEP/biblio.hfd -nk 000297 | SxmlIndent | more
Ou
HfdSelect -h $EXPLOR_AREA/Data/France/Analysis/biblio.hfd -nk 000297 | SxmlIndent | more
Pour mettre un lien sur cette page dans le réseau Wicri
{{Explor lien
|wiki= Wicri/Canada
|area= ParkinsonCanadaV1
|flux= France
|étape= Analysis
|type= RBID
|clé= ISTEX:4D2CD72C7E2B927E2AF68157BB11DCFC5A9F3D2C
|texte= Stereospecific prevention by 17β‐estradiol of MPTP‐induced dopamine depletion in mice
}}
| This area was generated with Dilib version V0.6.29. |  |